TABLE 1.
Gene ontology analysis of biological processes enriched in genes exhibiting decreased and increased expression levels with ERH knockdown in comparison to nontargeting siRNA controls
| Biological process | No. of genes | P value | q value |
|---|---|---|---|
| Decreased expression | |||
| Cell cycle process | 125 | 5.41 × 10−43 | 7.26 × 10−39 |
| Chromosome organization | 49 | 1.49 × 10−23 | 2.22 × 10−20 |
| Cell division | 49 | 7.09 × 10−19 | 9.53 × 10−16 |
| Chromatin assembly or disassembly | 24 | 2.27 × 10−16 | 1.79 × 10−13 |
| DNA metabolic process | 67 | 1.07 × 10−15 | 7.55 × 10−13 |
| Chromatin organization | 62 | 2.68 × 10−15 | 1.71 × 10−12 |
| Microtubule-based process | 50 | 5.58 × 10−15 | 3.4 × 10−12 |
| Nuclear division | 38 | 8.89 × 10−14 | 4.42 × 10−11 |
| Chromosome segregation | 22 | 4.87 × 10−14 | 2.51 × 10−11 |
| Protein complex assembly | 74 | 9.44 × 10−14 | 4.53 × 10−11 |
| Spindle organization | 20 | 4.52 × 10−13 | 1.9 × 10−10 |
| Organelle fission | 38 | 1.46 × 10−12 | 5.92 × 10−10 |
| Macromolecular complex assembly | 78 | 2.07 × 10−11 | 6.19 × 10−9 |
| Cell cycle checkpoint | 23 | 6.25 × 10−10 | 1.38 × 10−7 |
| Sister chromatid segregation | 10 | 1.09 × 10−9 | 2.28 × 10−7 |
| DNA conformation change | 18 | 2.08 × 10−9 | 4.17 × 10−7 |
| Regulation of organelle organization | 67 | 1.14 × 10−8 | 1.94 × 10−6 |
| DNA repair | 36 | 3.34 × 10−8 | 5.34 × 10−6 |
| DNA replication | 16 | 7.7 × 10−5 | 6.08 × 10−3 |
| Increased expression | |||
| Regulation of intracellular signal transduction | 87 | 1.3 × 10−9 | 1.75 × 10−5 |
| Regulation of cell death | 88 | 4.18 × 10−8 | 7.02 × 10−5 |
| Regulation of cell proliferation | 86 | 4.44 × 10−8 | 5.97 × 10−5 |
| Positive regulation of signaling | 83 | 1.73 × 10−7 | 1.66 × 10−4 |
| Extracellular matrix organization | 33 | 2.53 × 10−7 | 2.12 × 10−4 |
| Cell adhesion | 64 | 3.63 × 10−7 | 2.21 × 10−4 |
| Cell motility | 54 | 3.76 × 10−7 | 2.1 × 10−4 |
| Positive regulation of cell communication | 82 | 4.47 × 10−7 | 2.22 × 10−4 |
| Regulation of hydrolase activity | 70 | 2.59 × 10−6 | 9.4 × 10−4 |
| Regulation of protein metabolic process | 115 | 3.35 × 10−6 | 1.07 × 10−3 |
| Glycosaminoglycan biosynthetic process | 14 | 9.11 × 10−6 | 2.45 × 10−3 |
| Aminoglycan biosynthetic process | 14 | 1.02 × 10−5 | 2.69 × 10−3 |
| Positive regulation of response to stimulus | 92 | 1.35 × 10−5 | 3.12 × 10−3 |
| Regulation of proteolysis | 45 | 7.08 × 10−5 | 9.41 × 10−3 |
| Epithelium development | 20 | 8.99 × 10−5 | 1.14 × 10−2 |
| Tissue development | 39 | 1.07 × 10−4 | 1.28 × 10−2 |
| Regulation of cellular component movement | 40 | 1.24 × 10−4 | 1.43 × 10−2 |
| Chemotaxis | 20 | 7.57 × 10−4 | 5.01 × 10−2 |