TABLE 2.
Gene ontology analysis of biological processes enriched in genes exhibiting defective mRNA splicing in ERH-deficient cells in comparison to nontargeting controls
| Biological process | No. of genes | P value | q value |
|---|---|---|---|
| Nucleosome assembly | 20 | 5.4 × 10−9 | 6.57 × 10−5 |
| Protein heterotetramerization | 10 | 2.4 × 10−8 | 1.46 × 10−4 |
| Protein-DNA complex assembly | 21 | 2.96 × 10−8 | 1.2 × 10−4 |
| Nucleosome organization | 21 | 6.05 × 10−8 | 1.84 × 10−4 |
| Chromatin silencing at ribosomal DNA | 10 | 1.16 × 10−7 | 2.82 × 10−4 |
| DNA replication-dependent nucleosome organization | 9 | 1.31 × 10−7 | 2.65 × 10−4 |
| DNA replication-dependent nucleosome assembly | 9 | 1.31 × 10−7 | 2.27 × 10−4 |
| DNA methylation | 12 | 1.02 × 10−6 | 1.24 × 10−3 |
| DNA alkylation | 12 | 1.02 × 10−6 | 1.13 × 10−3 |
| Chromatin silencing | 10 | 1.87 × 10−5 | 1.75 × 10−2 |
| DNA modification | 13 | 4.6 × 10−5 | 3.73 × 10−2 |
| Methylation | 27 | 1.38 × 10−4 | 9.29 × 10−2 |
| Chromatin assembly or disassembly | 12 | 2.29 × 10−4 | 1.46 × 10−1 |
| Gene silencing | 12 | 2.62 × 10−4 | 1.59 × 10−1 |
| Protein heterooligomerization | 12 | 2.99 × 10−4 | 1.65 × 10−1 |
| Negative regulation of hematopoietic progenitor cell differentiation | 5 | 3.13 × 10−4 | 1.66 × 10−1 |
| Regulation of response to external stimulus | 40 | 4.29 × 10−4 | 2.17 × 10−1 |
| Reciprocal meiotic recombination | 6 | 6.42 × 10−4 | 3 × 10−1 |
| Reciprocal DNA recombination | 6 | 6.42 × 10−4 | 2.89 × 10−1 |
| Regulation of megakaryocyte differentiation | 5 | 9.36 × 10−4 | 4.06 × 10−1 |