Skip to main content
. 2015 May 20;309(3):R223–R234. doi: 10.1152/ajpregu.00238.2014

Fig. 3.

Fig. 3.

Characteristics of a model of reappearance of candidemia in sepsis (Candida+CLP). Serial blood candidemia within 24 h after Candida injection at 6 h before CLP (Candida+CLP) or NSS injection then CLP (NSS+CLP) or Candida injection with sham operation (Candida+Sham) (A) (n = 7/group) was demonstrated. The survival of different groups (B) (n = 15/group), cytokine responses including, proinflammatory cytokines (TNF-α, IL-6) (C and D), anti-inflammatory cytokines (IL-10) (E), fungal response cytokines (IL-17) (F) (n = 7/group), neutrophil count (G) (n = 5/group) are shown. Additionally, the comparison of germ tube growth in normal mouse serum and septic mouse serum is shown (H) (n = 3–5/group). Measured parameters (mean ± SE) were significantly different among the Candida+CLP, NSS+CLP, and Candida+Sham groups for fixed time point using one-way ANOVA followed by Bonferroni analysis with alpha set at 0.05 and three comparisons. (a,b,cP < 0.05, *,#,$P < 0.005, **,##,$$P < 0.0005; a, *, and ** denote Candida+CLP vs. NSS+CLP; b, #, and ## denote Candida+CLP vs. Candida+Sham; and c, $, and $$ denote NSS+CLP vs. Candida+Sham).