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. 2015 May 20;309(3):R223–R234. doi: 10.1152/ajpregu.00238.2014

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Fig. 7. — Low-dose amphotericin B with high-dose ascorbate improved survival of a model of reappearance of candidemia in sepsis (Candida+CLP). Survival analysis of mice treated with high-dose ascorbate alone (Asc+De-cholate), saline alone [normal saline solution (NSS)+De-cholate], and a therapeutic dose of amphotericin B (NSS+Ampho B 1 MK) (A) and the treatment with low-dose amphotericin B with and without ascorbate (Asc+Ampho B 0.1 MK and NSS+Ampho B 0.1 MK) or full-dose Ampho B without ascorbate (NSS+Ampho B 1 MK) in Candida+CLP model (B) is demonstrated. In addition, survival analysis is shown of reciprocal treatment in CLP mice in the absence of prior C. albicans inoculation (C) using the log-rank (Mantel-Cox) test (n = 20–22/group) *P < 0.01, #P < 0.05 between indicated time point.