Fig. 8.

Low-dose Ampho B with high-dose Asc attenuated severity of a model of reappearance of candidemia in sepsis (Candida+CLP). Sepsis severity parameters at 24 h of sham surgery models (Candida+Sham, NSS administered at 12 h and 18 h), Asc, or NSS administered with CLP surgery models (Candida+CLP with NSS or Asc administered at 12 h and 18 h), as measured by candidemia (A), peritoneal Candida (B), serum creatinine (Scr) (C), alanine transminase (ALT) (D), cytokines [TNF-α (E), IL-6 (F) IL-10 (G), and IL-17 (H)] are demonstrated (n = 5–7/group). Blood ascorbate level at 24 h of Acs injection was 15.2 ± 3.1 mM. Measured parameters (means ± SE) were significantly different among the Candida+Sham with NSS, Candida+CLP with Asc, and Candida+CLP with NSS groups for a fixed time point using one-way ANOVA, followed by Bonferroni analysis with alpha set at 0.05 and making three comparisons.