. 2015 Jul 22;2015:901015. doi: 10.1155/2015/901015

(a).

Gene symbol	Tissues	Fold change values at time points after infection relative to control
Gene symbol	Tissues	6 h	12 h	24 h	48 h	72 h
tlr1	Spleen	−1.07 ± 0.19	−1.02 ± 0.23	1.07 ± 0.16	−1.07 ± 0.18	−1.54 ± 0.28
	Head kidney	1.61 ± 0.18	1.72 ± 0.25	1.50 ± 0.27	1.57 ± 0.21	1.66 ± 0.13
	Liver	−1.11 ± 0.18	1.72 ± 0.31	2.32 ± 0.56	1.67 ± 0.31	1.70 ± 0.22
	Thymus	−1.31 ± 0.29	−1.20 ± 0.32	1.21 ± 0.29	1.13 ± 0.24	1.09 ± 0.20

tlr2	Spleen	−1.13 ± 0.16	−1.73 ± 0.33^∗	−1.86 ± 0.41^∗	−1.46 ± 0.15	−1.68 ± 0.20^∗
	Head kidney	1.24 ± 0.19	−1.13 ± 0.17	−1.68 ± 0.28	−1.10 ± 0.22	−1.18 ± 0.15
	Liver	−1.01 ± 0.11	−1.11 ± 0.11	−1.01 ± 0.12	1.50 ± 0.32	1.16 ± 0.18
	Thymus	−1.12 ± 0.21	−1.07 ± 0.19	−1.07 ± 0.25	1.16 ± 0.19	1.22 ± 0.16

tlr3	Spleen	−1.58 ± 0.17	−1.67 ± 0.25	−1.21 ± 0.25	−1.82 ± 0.23^∗	−1.70 ± 0.23^∗
	Head kidney	−1.52 ± 0.17^∗	−1.99 ± 0.26^∗	−2.49 ± 0.30^∗	−2.08 ± 0.29^∗	−2.09 ± 0.32^∗
	Liver	−1.21 ± 0.31	−1.64 ± 0.39	−1.40 ± 0.36	−1.83 ± 0.47	−1.64 ± 0.51
	Thymus	−1.26 ± 0.27	−1.87 ± 0.49	−1.46 ± 0.37	−1.52 ± 0.37	−1.63 ± 0.34

tlr5	Spleen	−2.77 ± 0.71	−3.88 ± 0.71^∗	−2.76 ± 0.70	−2.34 ± 0.66	−1.61 ± 0.49
	Head kidney	−1.07 ± 0.27	1.03 ± 0.64	−2.33 ± 0.48	−1.62 ± 0.47	−1.55 ± 0.34
	Liver	1.28 ± 0.31	−1.30 ± 0.25	1.77 ± 0.37	1.99 ± 0.37	1.96 ± 0.38
	Thymus	1.14 ± 0.23	−1.12 ± 0.29	−2.08 ± 0.35	−1.29 ± 0.30	−1.91 ± 0.52

tlr7	Spleen	−2.10 ± 0.24^∗	−1.62 ± 0.58	−2.79 ± 0.48^∗	−3.23 ± 0.62^∗	−3.40 ± 0.85^∗
	Head kidney	1.95 ± 0.45	2.22 ± 0.63	1.51 ± 0.49	−1.28 ± 0.35	−1.04 ± 0.24
	Liver	−1.01 ± 0.23	1.06 ± 0.19	1.17 ± 0.20	1.33 ± 0.41	−1.05 ± 0.30
	Thymus	−1.30 ± 0.28	−1.34 ± 0.33	−1.03 ± 0.40	−1.35 ± 0.28	−1.47 ± 0.31

tlr8a1	Spleen	−2.03 ± 0.29^∗	−1.76 ± 0.28^∗	−1.29 ± 0.20	−1.36 ± 0.23	−1.62 ± 0.29^∗
	Head kidney	−1.35 ± 0.22	−1.89 ± 0.39	−1.90 ± 0.34	−1.30 ± 0.45	−1.89 ± 0.77
	Liver	1.47 ± 0.41	1.81 ± 0.42	2.86 ± 0.77	2.88 ± 1.00	1.67 ± 0.43
	Thymus	1.02 ± 0.21	−1.01 ± 0.27	−1.09 ± 0.28	1.15 ± 0.28	−1.41 ± 0.30

tlr8a2	Spleen	−2.45 ± 0.53^∗	−1.99 ± 0.29^∗	−1.49 ± 0.27	−1.85 ± 0.32^∗	−2.75 ± 0.45^∗
	Head kidney	−1.31 ± 0.43	−1.46 ± 0.31	−1.23 ± 0.24	−1.29 ± 0.27	−1.91 ± 0.31
	Liver	1.54 ± 0.50	1.75 ± 0.56	2.30 ± 0.56	2.56 ± 0.81	1.54 ± 0.42
	Thymus	1.07 ± 0.27	−1.49 ± 0.33	−1.27 ± 0.32	1.03 ± 0.45	−1.28 ± 0.47

tlr9	Spleen	1.09 ± 0.11	1.32 ± 0.11	1.44 ± 0.17	1.20 ± 0.22	−2.00 ± 0.25^∗
	Head kidney	1.33 ± 0.19	1.35 ± 0.25	1.24 ± 0.21	1.29 ± 0.18	1.43 ± 0.17
	Liver	1.50 ± 0.22	1.95 ± 0.32	2.57 ± 0.42	2.87 ± 0.52^∗	3.44 ± 0.51^∗
	Thymus	−1.22 ± 0.37	−1.20 ± 0.40	1.15 ± 0.26	1.20 ± 0.39	1.33 ± 0.42

tlr19	Spleen	−1.22 ± 0.28	−1.66 ± 0.59	−1.62 ± 0.46	1.45 ± 0.38	−2.82 ± 0.66
	Head kidney	3.18 ± 0.84^∗	2.52 ± 0.54	2.73 ± 0.85	2.19 ± 0.64	2.00 ± 0.55
	Liver	2.83 ± 1.53	−1.82 ± 0.59	1.00 ± 0.23	−1.90 ± 0.54	−2.00 ± 0.57
	Thymus	1.06 ± 0.39	−1.22 ± 0.37	1.35 ± 0.55	1.02 ± 0.30	1.42 ± 0.43

tlr20	Spleen	−1.58 ± 0.29	−1.71 ± 0.38	−1.23 ± 0.21	1.08 ± 0.27	−1.02 ± 0.25
	Head kidney	1.29 ± 0.20	−1.40 ± 0.21	1.07 ± 0.17	1.24 ± 0.18	1.49 ± 0.21
	Liver	1.55 ± 0.23	1.74 ± 0.20	2.01 ± 0.19^∗	2.20 ± 0.25^∗	2.02 ± 0.26^∗
	Thymus	−1.17 ± 0.24	1.32 ± 0.35	−1.22 ± 0.32	1.19 ± 0.26	1.42 ± 0.31

tlr21	Spleen	−1.39 ± 0.28	−3.82 ± 0.46^∗	−1.83 ± 0.40	−1.25 ± 0.35	−1.03 ± 0.19
	Head kidney	−1.06 ± 0.26	−2.96 ± 0.61^∗	−3.36 ± 0.51^∗	−1.65 ± 0.26	−1.52 ± 0.24
	Liver	1.67 ± 0.48	1.61 ± 0.44	1.34 ± 0.21	2.16 ± 0.58	1.51 ± 0.34
	Thymus	1.07 ± 0.18	−1.31 ± 0.26	−1.47 ± 0.29	1.00 ± 0.21	−1.13 ± 0.21

tlr22a1	Spleen	1.21 ± 0.27	−1.18 ± 0.22	−1.10 ± 0.23	1.01 ± 0.27	−1.99 ± 0.45
	Head kidney	1.55 ± 0.50	1.41 ± 0.34	1.51 ± 0.56	1.06 ± 0.24	−1.75 ± 0.44
	Liver	2.12 ± 0.52	1.94 ± 0.43	2.50 ± 0.58	3.23 ± 1.00	1.41 ± 0.34
	Thymus	1.24 ± 0.21	−1.11 ± 0.29	1.11 ± 0.35	1.07 ± 0.23	−1.46 ± 0.23

tlr22a2	Spleen	3.02 ± 0.64	1.21 ± 0.24	1.11 ± 0.11	1.89 ± 0.39	1.53 ± 0.30
	Head kidney	6.14 ± 2.37^∗	3.81 ± 0.70^∗	1.63 ± 0.32	3.27 ± 0.70	2.71 ± 0.48
	Liver	3.51 ± 0.79	4.41 ± 0.97^∗	2.94 ± 0.85	3.85 ± 0.97^∗	3.12 ± 0.80
	Thymus	1.37 ± 0.25	1.83 ± 0.33	1.48 ± 0.40	1.23 ± 0.34	1.15 ± 0.28

nod1	Spleen	−1.05 ± 0.15	−1.60 ± 0.20	−1.01 ± 0.14	1.07 ± 0.12	−1.13 ± 0.13
	Head kidney	−1.22 ± 0.23	−3.08 ± 0.61^∗	−1.60 ± 0.26	−1.31 ± 0.32	−1.59 ± 0.35
	Liver	1.20 ± 0.18	1.26 ± 0.19	1.37 ± 0.19	1.36 ± 0.30	1.74 ± 0.34
	Thymus	−1.02 ± 0.21	1.45 ± 0.33	1.35 ± 0.39	−1.04 ± 0.27	−1.15 ± 0.26

^∗Significant expression difference (p < 0.05) between the infected and the control groups is indicated in bold.