[Table/Fig-9]:

Differences between HPV Positive and Negative SCC

	HPV Positive	HPV Negative
Biology and Mutation	p53 inhibited by E6. Rb inhibited by E7 Compensatory increase in p16	p53 gets mutated and hence inhibited p16 lost and hence pathways inactive
Histopathology	Poorly differentiated or basaloid SCC, presence of koilocytes	Well, moderately or poorly differentiated SCC with kertain pearls
Age	More commonly seen in younger individuals	More prevalent in older individuals
Risk Factors	Sexual factors	Tobacco, alcohol, diet, immunodeficiency
Location	Oropharyngeal region	Floor of month, lateral border of tongue
Prognosis	Good	Poor