[Table/Fig-1]:

OPN studies in various tumours

Author	Tumour	Study
Brown et al., [15]	Colon,stomach,duodenum, pancreas,duodenum, breast,lung,bladder, prostrate,ovary	In northern blot analysis-OPN mRNA & OPN protein by IHC detected but not detectable by ISH
Teruyoshi et al., [16]	Gastric carcinoma	In northern blot, ISH and IHC analysis- the OPN mRNA was over expressed of OPN was correlated with the progression of human gastric carcinoma.
Devoll et al., [17]	Premalignant and malignant lesions arising from oral epithelium.	Positive expression of OPN mRNA found using Northern blotting
Agarwal et al., [18]	Colon cancer	In oligonucleotide expression array, northern blot analysis and IHC. IHC technique-a highly significant correlation was found in colon cancer and adenomas (advanced staging)
Rudland et al., [19]	Breast cancer (stage I &II)	Western blotting technique and IHC results suggest that the OPN is tightly correlated with patient demise.
Coppola et al., [20]	Breast, Ovary, Endometrium, esophagus, stomach, pancreas, bileduct, liver, colon, kidney, bladder, prostate, Head & neck, salivary gland, lung, skin and brain	Significant OPN staining in a large percentage of the gastric, colon, pancreatic, renal, lung, endometric, esophageal, head and neck tumours The strong correlation between pathological stage and OPN across multiple tumour types suggested its role in tumour progression
Celetti et al., [21]	Laryngeal Squamous cell carcinomas	In IHC, immunoblotting and RT-PCR - the OPN expression was closely correlated with advanced stage, high grade metastatic disease and poor survival
Donati et al., [22]	Non-small cell lung cancer (stage I)	In IHC- high OPN expression associate poor survival rate with non –small cell lung cancer
Kita et al., [23]	ESCC	In IHC-the OPN expression is useful for predicting the malignant properties of ESCC.
Matsuzaki et al., [24]	Squamous cell carcinoma(SCC) of the tongue	OPN immunohistochemical staining showed a remarkable increase at the invasion front compared with the non-invaded regions
Tigrani et al., [25]	Epithelioid mesotheliomas & reactive mesotheilal proliferation	The immunohistochemical expression of OPN usefulness in distinguishing reactive mesothelial proliferation from malignancy
Chien et al., [26]	Tongue cancers (T1&T2)	The positive expression of OPN significantly correlated with relatively advanced, nodal status, tumour necrosis and tumour thickness
WU et al., [27]	ESCC	OPN was associated with the development of ESCC, but no significant associations between these protein expressions and patient’s cancer stage or survival.
Zhang et al., [28]	Epithelial ovarian tumours	The positive immune reactivity of OPN & B7-H4 was higher in poorly differentiated ovarian cancer than in medium and highly differentiated ovarian cancer
Ogbureke et al., [29]	Oral Premalignant Lesions	Bone sialoprotein and Dentin Sialophosphoproteins expression pattern correlated with decreased transformation to OSCC.
Han WH et al., [30]	Human nasopharyngeal carcinoma	In IHC & western blotting methods- OPN expression significantly related to tumour size, regional lymph node metastasis