[Table/Fig-2]:

OPN studies in various body fluids -plasma, serum & salivary secretion

Author	Tumour	Study
Fedarko et al.,[37]	Prostate, colon, breast, lung carcinomas	In competitive ELISA assay, provided a high degree of sensitivity and specificity informative markers the detection of colon, breast, prostate & lung cancer
Kim et al., [38]	Epithelial ovarian cancer	Plasma OPN were significantly higher in epithelial ovarian cancer (486.5ng/ml), benign lesion (254.4ng/ml) & compared with healthy controls (147.1ng/ml)- RT-PCR & ELISA
Katakura et al.,[39]	Oral cancer	The elevated levels of interleukins-IL-1β, IL6, IL8 and OPN in the saliva of the oral cancer patient by ELISA method
Thu Le Q et al.,[40]	Head & neck Squamous cell carcinoma	Significantly higher plasma OPN levels correlates relapse, survival rate and tumour recurrence
Koopmans et al.,[41]	Pancreatic adenocarcinoma	Serum OPN levels were elevated in pancreatic adenocarcinoma as a diagnostic marker
Bramwell et al.,[42]	Metastatic breast cancer	The increased level of OPN were strongly associated with poor survival and used in making treatment decisions
Petrik et al.,[43]	Head and Neck Squamous cell carcinoma	Plasma OPN level was elevated in uncontrolled tumour (642ng/ml) correlates tumour control rate, event –free survival and post relapse survival
Cho et al., [44]	Cervical cancer	plasma OPN levels are potentially useful as diagnostic and prognostic biomarker for cervical cancer
Zhou et al.,[45]	Oral Lichen Planus-premalignant lesion	In ELISA, The serum concentration of OPN and TNF- α were significantly higher in OLP patient than the normal control