Table 1. Description of K. pneumoniae subsp. pneumoniae isolates against which phage KLPN1 was screened.
| Straina | Capsular type (K PCR result)b | rmpA | wcaG | Source | Infected by phage KLPN1 |
|---|---|---|---|---|---|
| L4-FAA5 | K2 | + | – | Human caecal effluent | Yes |
| K/5216 | K1 (K1 cluster of CC23) | + | + | Liver abscess (Taiwan) | No |
| NCTC 5055 | K2 (reference strain) | + | – | Human | Yesd |
| NCTC 9660 | K5 (reference strain) | – | – | Cloacae of horse | No |
| PHE1 | – | – | – | Rectal swab | No |
| PHE2 | – | – | – | Human clinical | No |
| PHE3 | – | – | – | Sputum, transplant patient | No |
| PHE4 | – | – | – | Urine, spinal injury patient | No |
| PHE5 | – | – | – | Human blood | No |
| PHE6 | – | – | + | Urine, incontinent patient | No |
| PHE7 | – | – | – | Human clinical | No |
| PHE8 | – | – | – | Human blood | No |
| PHE9 | – | – | – | Human clinical | No |
| PHE10 | – | – | – | Human blood | No |
| PHE11c | K2 | – | – | Blood, patient with urinary tract infection | Yesd |
| PHE12c | K2 | – | – | Urine | Yesd |
| PHE13 | K2 | – | – | Blood and sputum, patient with bacteraemia and pneumonia | Yesd |
| PHE14 | K2 | + | – | Sputum, patient with bacteraemia | Yesd |
| PHE15 | K2 | – | – | Urine, cardiac patient | Yesd |
| PHE16 | K20 | + | – | Sputum, transplant patient | No |
| PHE17 | K54 | – | + | Intensive care unit | No |
| PHE18 | K57 | – | – | Sputum, transplant patient | No |
Notes.
- nd
- No data
a
Strains with the prefix PHE were submitted for typing by healthcare providers to Public Health England–Colindale. Each isolate represented a distinct strain, with the exception of isolates PHE11 and PHE12.
b
K PCR can detect K1, K2, K5, K20, K54 and K57 capsular types.
c
Corresponds to multi-locus sequence type ST14, often seen among multi-drug-resistant isolates producing carbapenemases.
d
Phage KLPN1 did not exhibit depolymerase activity on these K2 isolates, but it did on L4-FAA5.