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. 2004 Jul;15(7):3132–3145. doi: 10.1091/mbc.E04-02-0103

Figure 1.

Figure 1.

(A) Immunoblot analysis of extracts from mouse embryonic fibroblasts derived from E12.5 embryos. The expression of lysosomal membrane proteins LAMP-1, LAMP-2, and LIMP-2/LGP-85 was analyzed. (B-G) Macroscopic phenotype of LAMP-1/LAMP-2-deficient embryos (C, D, E, and G) in comparison with control (LAMP-1+/+/LAMP-2+/+ littermates; B and F). (H) Microscopic organization of the organs of a double-deficient embryo (E12) as seen in a transversal section. NT, neural tube. DRG, dorsal root ganglion. Br, bronchus. H, heart. Semithin section, toluidine blue. Bars in B-E, 5 mm; F and G, 2 mm; H, 0.5 mm.