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. Author manuscript; available in PMC: 2016 Mar 26.
Published in final edited form as: Cell. 2015 Mar 26;161(1):161–172. doi: 10.1016/j.cell.2015.01.036

Figure 2. Feedback Regulation of Cholesterol Synthesis and LDL Receptors in Cultured Cells from Normal Subjects and Children with Homozygous FH.

Figure 2

(A) Normal cells obtain cholesterol from two sources: 1) endogenous synthesis and 2) receptor-mediated uptake and lysosomal hydrolysis of LDL.

(B) Lacking LDL receptors, FH cells maintain normal levels of cholesterol by increasing synthesis of cholesterol, leaving excess LDL in the culture medium.