Table 1.
Differentially regulated plasma membrane proteins identified in GC tissues
| Accession No. | Gene symbols | Description | TMT ratio | P value | Function |
|---|---|---|---|---|---|
| Q12959 | DLG1 | discs, large homolog 1 (Drosophila) | -8.78 | 1.28E-05 | kinase |
| G8JLH6 | CD9 | CD9 molecule | -3.723 | 7.04E-02 | other |
| P30453 | HLA-A | major histocompatibility complex, class I, A | -2.903 | 7.40E-04 | other |
| O95810 | SDPR | serum deprivation response | -2.623 | 1.69E-09 | other |
| P48960 | CD97 | CD97 molecule | -2.615 | 3.74E-01 | G-protein coupled receptor |
| Q16853 | AOC3 | amine oxidase, copper containing 3 | -2.314 | 1.11E-10 | enzyme |
| E7EWP3 | MPZ | myelin protein zero | -2.266 | 2.45E-07 | other |
| Q03135 | CAV1 | caveolin 1, caveolae protein, 22 kDa | -2.251 | 2.43E-10 | transmembrane receptor |
| P41219 | PRPH | peripherin | -2.149 | 1.65E-08 | other |
| P43121 | MCAM | melanoma cell adhesion molecule | -2.115 | 1.93E-09 | other |
| Q9HAV0 | GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -1.976 | 9.69E-04 | enzyme |
| Q86UP2 | KTN1 | kinectin 1 (kinesin receptor) | -1.959 | 7.69E-03 | transmembrane receptor |
| P01859 | IGHG2 | immunoglobulin heavy constant gamma 2 (G2m marker) | -1.844 | 1.43E-02 | other |
| B7Z2R4 | SGCE | sarcoglycan, epsilon | -1.791 | 2.91E-02 | other |
| P18206 | VCL | vinculin | -1.685 | 2.01E-10 | enzyme |
| A0FGR8 | ESYT2 | extended synaptotagmin-like protein 2 | -1.672 | 2.68E-03 | other |
| P08133 | ANXA6 | annexin A6 | -1.668 | 1.10E-11 | ion channel |
| O43491 | EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -1.66 | 1.05E-08 | other |
| Q14BN4 | SLMAP | sarcolemma associated protein | -1.645 | 6.33E-04 | other |
| A6NMH8 | CD81 | CD81 molecule | -1.634 | 3.17E-04 | other |
| Q96CX2 | KCTD12 | potassium channel tetramerization domain containing 12 | -1.559 | 3.59E-08 | ion channel |
| Q9H223 | EHD4 | EH-domain containing 4 | -1.527 | 1.30E-03 | enzyme |
| Q13418 | ILK | integrin-linked kinase | -1.526 | 1.20E-09 | kinase |
| P16671 | CD36 | CD36 molecule (thrombospondin receptor) | -1.501 | 1.16E-06 | transmembrane receptor |
| P38606 | ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | 1.514 | 3.79E-05 | transporter |
| Q14108 | SCARB2 | scavenger receptor class B, member 2 | 1.514 | 1.92E-08 | other |
| P01903 | HLA-DRA | major histocompatibility complex, class II, DR alpha | 1.521 | 2.94E-08 | transmembrane receptor |
| Q14444 | CAPRIN1 | cell cycle associated protein 1 | 1.529 | 1.30E-06 | other |
| Q6IAA8 | LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | 1.533 | 5.18E-03 | other |
| P27216 | ANXA13 | annexin A13 | 1.536 | 3.38E-09 | other |
| Q9Y287 | ITM2B | integral membrane protein 2B | 1.553 | 7.16E-02 | other |
| Q9Y6R1 | SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 1.558 | 2.21E-04 | transporter |
| Q8WVV4 | POF1B | premature ovarian failure, 1B | 1.568 | 9.94E-09 | other |
| D6RH31 | NPNT | nephronectin | 1.59 | 1.40E-05 | other |
| Q9P0L0 | VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33 kDa | 1.597 | 7.50E-06 | other |
| P02786 | TFRC | transferrin receptor | 1.602 | 3.53E-01 | transporter |
| O00203 | AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 1.619 | 5.16E-03 | transporter |
| Q00610 | CLTC | clathrin, heavy chain (Hc) | 1.623 | 6.18E-11 | other |
| P26006 | ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 1.645 | 3.24E-08 | other |
| O95292 | VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 1.652 | 4.17E-05 | other |
| B4DNJ6 | STRAP | serine/threonine kinase receptor associated protein | 1.654 | 4.56E-03 | other |
| B5MCA4 | EPCAM | epithelial cell adhesion molecule | 1.655 | 4.47E-03 | other |
| Q14247 | CTTN | cortactin | 1.664 | 2.58E-06 | other |
| C9JME2 | FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 1.667 | 4.07E-10 | other |
| P15144 | ANPEP | alanyl (membrane) aminopeptidase | 1.693 | 7.85E-10 | peptidase |
| G5EA09 | SDCBP | syndecan binding protein (syntenin) | 1.71 | 1.01E-06 | enzyme |
| O75955 | FLOT1 | flotillin 1 | 1.727 | 2.09E-02 | other |
| Q86XK7 | VSIG1 | V-set and immunoglobulin domain containing 1 | 1.727 | 1.27E-04 | other |
| P00533 | EGFR | epidermal growth factor receptor | 1.755 | 2.27E-01 | kinase |
| P17301 | ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 1.786 | 1.19E-08 | transmembrane receptor |
| P29992 | GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 1.786 | 7.56E-02 | enzyme |
| C9J6P4 | ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 1.835 | 3.35E-09 | other |
| P27105 | STOM | stomatin | 1.844 | 1.31E-04 | other |
| P46977 | STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 1.895 | 5.89E-05 | enzyme |
| Q9BX66 | SORBS1 | sorbin and SH3 domain containing 1 | 1.895 | 1.62E-08 | other |
| O95563 | MPC2 | mitochondrial pyruvate carrier 2 | 1.917 | 2.32E-08 | other |
| P09496 | CLTA | clathrin, light chain A | 1.926 | 1.13E-12 | other |
| Q13155 | AIMP2 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | 1.928 | 1.03E-07 | other |
| P09497 | CLTB | clathrin, light chain B | 1.954 | 1.00E-10 | other |
| H9KV28 | DIAPH1 | diaphanous-related formin 1 | 1.958 | 8.62E-04 | other |
| Q99720 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | 1.961 | 3.62E-04 | G-protein coupled receptor |
| P13473 | LAMP2 | lysosomal-associated membrane protein 2 | 1.999 | 5.05E-10 | enzyme |
| F5H7K4 | NCEH1 | neutral cholesterol ester hydrolase 1 | 2.006 | 5.68E-04 | enzyme |
| P11215 | ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 2.012 | 2.29E-10 | transmembrane receptor |
| P15924 | DSP | desmoplakin | 2.031 | 8.86E-13 | other |
| Q9UGM3 | DMBT1 | deleted in malignant brain tumors 1 | 2.079 | 2.59E-06 | transmembrane receptor |
| Q93008 | USP9X | ubiquitin specific peptidase 9, X-linked | 2.19 | 1.22E-01 | peptidase |
| O15400 | STX7 | syntaxin 7 | 2.208 | 1.94E-07 | transporter |
| Q9BXJ0 | C1QTNF5 | C1q and tumor necrosis factor related protein 5 | 2.223 | 2.33E-04 | transmembrane receptor |
| Q9UJZ1 | STOML2 | stomatin (EPB72)-like 2 | 2.228 | 1.06E-04 | other |
| P55011 | SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 2.332 | 5.91E-11 | transporter |
| O00182 | LGALS9 | lectin, galactoside-binding, soluble, 9 | 2.45 | 1.39E-05 | other |
| Q08380 | LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 2.469 | 4.66E-06 | transmembrane receptor |
| Q9UGI8 | TES | testis derived transcript (3 LIM domains) | 2.577 | 1.55E-06 | other |
| Q9NZ01 | TECR | trans-2,3-enoyl-CoA reductase | 2.83 | 1.45E-07 | enzyme |
| G3V1K3 | PON2 | paraoxonase 2 | 2.932 | 3.93E-06 | enzyme |
| O95841 | ANGPTL1 | angiopoietin-like 1 | 3.109 | 4.33E-04 | other |
| Q92542 | NCSTN | nicastrin | 3.634 | 3.58E-02 | peptidase |
| O95497 | VNN1 | vanin 1 | 3.718 | 1.00E-08 | enzyme |
| P16144 | ITGB4 | integrin, beta 4 | 3.792 | 2.40E-01 | transmembrane receptor |
| Q96HR9 | REEP6 | receptor accessory protein 6 | 3.797 | 2.70E-08 | other |
| P48230 | TM4SF4 | transmembrane 4 L six family member 4 | 4.71 | 1.42E-04 | other |