Table 2.
Clinico-pathological factors associated with DNMT1 overexpression in astrocytic tumour patients from simple logistic regression analysis
| Variables | Regression coefficient (B) | Crude OR (CI 95%) | Wald statistic (df) | P-value |
|---|---|---|---|---|
| Age | 0.044 | 1.045 (1.009, 1.082) | 6.086 (1) | 0.014 |
| Race | ||||
| Chinese | 0 | 1 | ||
| Malay | -20.161 | <0.001 | <0.001 (1) | 0.999 |
| Sex | ||||
| Female | 0 | 1 | ||
| Male | 0.189 | 1.208 (0.414, 3.525) | 0.120 | 0.729 |
| Site | ||||
| Infratentorial | 0 | 1 | ||
| Supratentorial | 0.118 | 1.125 (0.264, 4.795) | 0.025 (1) | 0.873 |
| Tumour grade | ||||
| Low grade | 0 | 1 | ||
| High grade | 2.091 | 8.094 (2.304, 10.433) | 10.640 (1) | 0.001 |
| WHO grade | ||||
| I | 0 | 1 | ||
| II | 1.076 | 2.933 (0.657, 13.093) | 1.988 (1) | 0.159 |
| III | 1.769 | 5.867 (1.075, 32.002) | 4.178 (1) | 0.041 |
| IV | 3.728 | 41.600 (4.219, 410.222) | 10.194 (1) | 0.001 |
| MGMT protein | ||||
| Expression | ||||
| OE | 0 | 1 | ||
| RE | -0.151 | 0.860 (0.208, 3.550) | 0.043 (1) | 0.835 |
| Percentage | -0.015 | 0.985 (0.956, 1.015) | 0.937 (1) | 0.333 |
| H-score | -0.002 | 0.998 (0.985, 1.011) | 0.092 (1) | 0.762 |
| H-score level | ||||
| ≥23 (High) | 0 | 1 | ||
| <23 (Low) | 0.206 | 1.229 (0.332, 4.542) | 0.095 (1) | 0.758 |
OE: overexpression, RE: reduced expression, OR: odd ratio, df: degree of freedom, CI: confident interval.