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. 2015 Jun 1;8(6):6214–6224.

Figure 4.

Figure 4

Effect of mannose on PPARγ, MR, and TGF-β1 expression in lungs of ALI mice. Mice randomly received a saline solution or mannose by intravenous injection in the tail vein 5 min before and 3 h after intratracheal instillation of LPS (4 mg/kg). Samples were collected 6 h after administration of LPS and detected by real-time RT-PCR and western blot. A. Measurement of PPARγ mRNA levels. B. Measurement of MR mRNA levels. C. Measurement of TGF-β1 mRNA levels. D. Measurement of PPARγ, MR, and TGF-β1 protein production. Lane 1 lung tissues from control group, lane 2 from LPS group, lanes 3, 4, 5 and 6 from treatment group with mannose (50, 150, 450 mg/kg) and DXM, β-actin was sued as a control. The data represent the mean ± SD of three independent experiments. *P<0.05 and **P<0.01 vs. control group; #P<0.05 and ##P<0.01 vs. LPS group.