Table 3.
Cox multivariate regression analyses for the influence of PNI on overall and disease-free survival in locally advanced ESCC
| Variables | Hazard Ratio | P | 95% CI |
|---|---|---|---|
| Overall survival | |||
| PNI | 1.832 | 0.001 | 1.267-2.651 |
| Age | 1.232 | 0.215 | 0.866-1.714 |
| Sex | 0.838 | 0.336 | 0.585-1.201 |
| Location (baseline, Proximal esophagus) | |||
| Mid esophagus | 0.924 | 0.808 | 0.489-1.745 |
| Distal esophagus | 1.028 | 0.937 | 0.519-2.037 |
| Differentiation (baseline, Well) | |||
| Moderately | 0.840 | 0.447 | 0.193-2.064 |
| Poorly | 0.943 | 0.922 | 0.291-3.051 |
| AJCC stage | 1.949 | < 0.001 | 1.365-2.784 |
| Blood vessel invasion | 1.124 | 0.512 | 0.793-1.592 |
| Postoperative radiotherapy | 1.743 | 0.001 | 1.263-2.404 |
| Disease-free survival | |||
| PNI | 1.513 | 0.026 | 1.051-2.177 |
| Age | 1.088 | 0.612 | 0.785-1.508 |
| Sex | 0.832 | 0.384 | 0.794-1.818 |
| Location (baseline, Proximal esophagus) | |||
| Mid esophagus | 0.864 | 0.652 | 0.459-1.629 |
| Distal esophagus | 0.914 | 0.796 | 0.463-1.805 |
| Differentiation (baseline, Well) | |||
| Moderately | 0.71 | 0.57 | 0.218-2.317 |
| Poorly | 0.976 | 0.967 | 0.3-3.168 |
| AJCC stage | 1.958 | < 0.001 | 1.376-2.787 |
| Blood vessel invasion | 1.071 | 0.694 | 0.761-1.508 |
| Postoperative radiotherapy | 1.588 | 0.005 | 1.148-2.197 |