Table 3.
Univariate analysis of factors associated with DFS and OS
| Variables | DFS | OS | |||
|---|---|---|---|---|---|
|
|
|
||||
| Median survival time (m) | p-value | Median survival time (m) | p-value | ||
| Hoxb-13 expression | Low | 18 | < 0.001 | 28 | < 0.001 |
| High | 7 | 11 | |||
| Age (years) | < 60 | 9 | 0.462 | 11 | 0.309 |
| ≥ 60 | 10 | 20 | |||
| Gender | Male | 9 | 0.475 | 15 | 0.496 |
| Female | 9 | 20 | |||
| Tumor diameter | < 20 mm | 9 | 0.982 | 21 | 0.574 |
| ≥ 20 mm | 9 | 14 | |||
| Tumor location | Head | 9 | 0.853 | 20 | 0.528 |
| Body/tail | 9 | 15 | |||
| Histological grade | Mod-poor | 7 | < 0.001 | 11 | < 0.001 |
| Well | 16 | 27 | |||
| Perineural invasion | Absent | 15 | < 0.001 | 28 | < 0.001 |
| Present | 8 | 11 | |||
| LNM | Absent | 15 | < 0.001 | 24 | 0.005 |
| Present | 8 | 11 | |||
| Distant metastasis | Absent | 15 | < 0.001 | 25 | < 0.001 |
| Present | 7 | 11 | |||
| TNM stage | I-II | 14 | < 0.001 | 25 | 0.001 |
| III-IV | 8 | 13 | |||
| Serum CA19-9 | ≤ 37 U/ml | 11 | 0.018 | 24 | 0.050 |
| > 37 U/ml | 8 | 14 | |||
Homeobox, Hoxb; LNM, lymph node metastasis; TNM, tumor-node-metastasis; CA19-9, carbohydrate antigen19-9; DFS, disease-free survival; OS, overall survival.