Table 1.

Polymorphisms and frequency distribution of CYP3A4 in Uyghur population

#	SNP ID	Position	Region	Allele	Effect	Flanking Sequence	MAF
1	/	-747C > G	Promoter	CYP3A4*1F	/	TGTACAGCAC S CTGGTAGGGA	0.025
2	/	-667C > T	Promoter	CYP3A4*1W	/	GGGAAACAGG Y GTGGAAACAC	0.005
3	new1	-549C > G	Promoter		/	AGGAAAGACT S TAAGAGAAGG	0.005
4	rs2740574	-392A > G	Promoter	CYP3A4*1B	/	GACAAGGGCA R GAGAGAGGCG	0.015
5	/	-62C > A	5’UTR	CYP3A4*1D	/	CATAGCCCAG M AAAGAGCAAC	0.005
6	rs55913187	3858C > T	Intron1		Not translated	TAATCATTGC Y GTCAGAGTTA	0.015
7	new2	5939A > T	Intron5		Not translated	TTTTCATCCC W ATTAGAGGCA	0.005
8	/	13908G > A	Exon5	CYP3A4*8	130R > Q	AAGAGATTAC R ATCATTGCTG	0.005
9	new3	15380C > T	Intron6		Not translated	TCACACCCAG Y GTAGGGCCAG	0.015
10	/	15727G > C	Intron7	CYP3A4*1P	Not translated	TAAGTATGTG S ACTACTATTT	0.015
11	/	15753T > C	Intron7	T15781G*	Not translated	TATTTATCTT Y CTCTCTTAAA	0.025
12	/	15977T > C	Intron7	C78013T*	Not translated	AACTTTCTGC Y TCTATGGATT	0.740
13		16613C > T	Intron7	C78649T*	Not translated	ACTGCTGTAG Y GGTGCTCCTT	0.115
14	new4	16934A > T	Exon8		264T > S	CCTCGAAGAT W CACAAAAGGT	0.005
15	new5	17864A > C	Intron9		Not translated	AGAGGCATGC M GGCATAGATA	0.005
16	rs2242480	20230G > A	Intron10	CYP3A4*1G	Not translated	TGAGTGGATG R TACATGGAGA	0.115
17	rs4986910	23172T > C	Exon12	CYP3A4*3	445M > T	TGCATTGGCA Y GAGGTTTGCT	0.005
18	new7	25721A > G	Intron12		Not translated	ATTACTCCAT R GAGATCAGAA	0.130
19	new8	25925C > T	Exon13		499T > T	GGGATGGCAC Y GTAAGTGGAG	0.010
20	new9	25931T > C	Exon13		501S > S	GCACCGTAAG Y GGAGCCTGAA	0.005
21	new10	26759G > C	3’UTR		/	TGGTGGACTC S CCTGTAATCT	0.005

MAF: minor allele frequency.