Table 1.

Expression of VEGF and HIF-1

Time course (hours)	VEGF		HIF-1α
	Normoxia	Hypoxia	Normoxia	Hypoxia
0	1.00 (0.82~1.22)*	0.00 (0.00~0.00)	1.00 (0.83~1.21)	0.43 (0.36~0.52)
8	0.15 (0.13~0.19)	0.06 (0.05~0.08)	0.39 (0.31~0.49)	0.75 (0.63~0.89)
24	0.94 (0.80~1.11)*	0.16 (0.13~0.19)	0.55 (0.46~0.66)	8.36 (5.23~13.37)*
72	0.05 (0.04~0.06)	0.20 (0.17~0.24)*	0.06 (0.05~0.07)	6.09 (5.11~7.25)*

The genes expression levels were calcaulted by the 2^-ΔΔCT method. Data were presented as 2^-ΔΔCT and range.

^*Indicated significance (p < 0.05) when compared with normoxia or hypoxia.

VEGFA, vascular endothelial growth factor A; HIF-1, hypoxia-inducible factor-1.