Table 3.

Logistic regression analyses of associations between miRNA-related SNPs and risk of ESCC

genotype	Cases (n=248)	n%	Controls (n=300)	n%	crude OR (95% CI)	P	Adjusted ORa (95% CI)	P
(miR100) rs1834306
TT	54	21.8	46	15.6	1.00		1.00
TC	109	44.0	97	33.0	0.957 (0.593-1.546)	0.858	0.955 (0.590-1.947)	0.853
CC	85	34.2	151	51.4	0.480 (0.298-0.771)	0.002	0.480 (0.298-0.772)	0.002
TT vs. TC vs. CC								3.34×10-4
TC+CC	194	78.2	248	84.4	0.666 (0.431-1.030)	0.068	0.665 (0.430-1.031)	0.067
TT+TC	163	65.8	143	48.6	1.00		1.00
CC	85	34.2	151	51.4	0.494 (0.349-0.699)	7.06×10-5	0.495 (0.349-0.702)	8.05×10-5
T allele	217	43.8	189	32.1	1.00
C allele	279	56.2	399	52.9	0.609 (0.48-0.78)	8.37×10-5
(miR34b/c) rs4938723
TT	113	47.7	122	44.5	1.00		1.00
TC	99	41.8	122	44.5	1.11 (0.62-2.00)	0.725	1.07 (0.59-1.94)	0.824
CC	25	10.5	30	10.9	0.97 (0.54-1.76)	0.930	0.95 (0.52-1.73)	0.868
TT vs. TC vs. CC								0.772
TC+CC	124	52.3	152	55.5	1.14 (0.80-1.610	0.476	1.11 (0.78-1.58)	0.547
TT+TC	212	89.5	244	89.1	1.00		1.00
CC	25	10.5	30	10.9	1.04 (0.60-1.83)	0.884	1.01 (0.57-1.78)	0.975
T allele	325	68.6	366	66.8	1
C allele	149	31.4	182	33.2	1.09 (0.83-1.41)	0.545
(miR375) rs6715345
GG	158	92.4	163	89.6	1.00		1.00
CG	7	4.1	15	8.2	0.481 (0.191-1.212)	0.121	0.481 (0.190-1.218)	0.123
CC	6	3.5	4	2.1	1.547 (0.429-5.588)	0.505	1.495 (0.410-0.450)	0.542
GG vs. CG vs. CC								0.218
CG+CC	13	7.6	19	10.4	0.706 (0.337-1.477)	0.355	0.698 (0.332-1.467)	0.343
GG+CG	165	96.5	178	97.8	1.00		1.00
CC	6	3.5	4	2.1	1.618 (0.449-5.836)	0.462	1.561 (0.429-5.683)	0.500
G allele	323	94.4	341	93.7	1.00
C allele	19	5.6	23	6.3	1.15 (0.61-2.15)	0.668
(miR146a) rs2910164
GG	82	34.5	99	35.6	1.00		1.00
CG	120	50.4	139	50	1.087 (0.64-1.86)	0.762	1.07 (0.62-1.83)	0.811
CC	36	15.1	40	14.4	1.04 (0.71-1.53)	0.831	1.03 (0.70-1.51)	0.890
GG vs. CG vs. CC								0.951
CG+CC	156	65.5	179	64.4	0.95 (0.66-1.37)	0.784	0.97 (0.67-1.39)	0.847
GG+CG	202	84.9	238	85.6	1.00		1.00
CC	36	15.1	40	14.4	0.94 (0.58-1.54)	0.814	0.95 (0.58-1.55)	0.842
G allele	284	59.7	337	60.6	1.00
C allele	192	40.3	219	39.4	0.96 (0.75-1.23)	0.757
(miR423) rs6505162
CC	99	40.9	109	38.9	1.00		1.00
CA	122	50.4	140	50	0.959 (0.666-1.382)	0.824	0.955 (0.662-1.378)	0.805
AA	21	8.7	31	11.1	0.746 (0.402-1.383)	0.352	0.753 (0.405-1.400)	0.371
CC vs. CA vs. AA								0.644
CA+AA	143	59.1	171	61.1	0.921 (0.648-1.308)	0.645	0.918 (0.646-1.306)	0.635
CC+CA	221	91.3	249	88.9	1.00		1.00
AA	21	8.7	31	11.1	0.763 (0.426-1.367)	0.364	0.773 (0.430-1.389)	0.389
C allele	320	66.1	358	63.9	1.00
A allele	164	33.9	202	36.1	1.10 (0.85-1.42)	0.460
(miR373) rs12983273
CC	109	72.7	199	72.1	1.00		1.00
CT	37	24.6	64	23.2	1.055 (0.661-1.684)	0.821	1.053 (0.659-1.684)	0.828
TT	4	2.7	13	4.7	0.562 (0.179-1.765)	0.323	0.556 (0.176-1.753)	0.316
CC vs. CT vs. TT								0.626
CT+TT	41	27.3	77	27.9	0.972 (0.623-1.517)	0.901	0.969 (0.620-1.514)	0.890
CC+CT	146	97.3	263	95.3	1.00		1.00
TT	4	2.7	13	4.7	0.554 (0.177-1.731)	0.310	0.549 (0.175-1.720)	0.303
C allele	255	85	462	83.7	1.00
T allele	45	15	90	16.3	1.10 (0.75-1.63)	0.618

^aAdjusted for age, sex and clinical features in a logistic regression model;

Bold values are statistically significant (P<0.05).