Table 4.
Association of NCOA2 polymorphisms with obesity and dyslipidemia
| SNPs | Models | OR (95% CI) | P * | Adjusted OR (95%CI)# | Adjusted P # | AIC | |
|---|---|---|---|---|---|---|---|
| Obesity | rs41391448 | Codominant | 0.83 (0.40-1.72) | 0.61 | 0.83 (0.40-1.73) | 0.62 | 336.0 |
| 0.75 (0.09-5.92) | 0.78 | 0.70 (0.09-5.64) | 0.74 | ||||
| Dominant | 0.82 (0.41-1.65) | 0.57 | 0.82 (0.41-1.65) | 0.57 | 334.0 | ||
| Recessive | 0.78 (0.10-6.14) | 0.80 | 0.73 (0.09-5.83) | 0.76 | 334.2 | ||
| Overdominant | 0.84 (0.40-1.73) | 0.62 | 0.84 (0.41-1.74) | 0.64 | 334.1 | ||
| Multiplicative | 0.84 (0.45-1.56) | 0.57 | 0.84 (0.45-1.55) | 0.56 | 334.0 | ||
| rs10504473 | Codominant | 0.91 (0.43-1.93) | 0.81 | 0.94 (0.44-2.01) | 0.88 | 335.7 | |
| 1.77 (0.82-3.82) | 0.14 | 1.81 (0.84-3.90) | 0.13 | ||||
| Dominant | 1.19 (0.61-2.36) | 0.60 | 1.23 (0.62-2.45) | 0.54 | 337.3 | ||
| Recessive | 1.88 (1.02-3.45) | 0.047 | 1.87 (1.02-3.44) | 0.048 | 333.8 | ||
| Overdominant | 0.67 (0.37-1.21) | 0.18 | 0.68 (0.38-1.24) | 0.21 | 336.1 | ||
| Multiplicative | 1.38 (0.92-2.07) | 0.12 | 1.39 (0.93-2.09) | 0.11 | 335.1 | ||
| Dyslipidemia | rs41391448 | Codominant | 0.84 (0.55-1.29) | 0.43 | 0.84 (0.55-1.29) | 0.43 | 683.8 |
| 0.61 (0.19-1.97) | 0.41 | 0.61 (0.19-1.98) | 0.42 | ||||
| Dominant | 0.82 (0.54-1.23) | 0.34 | 0.82 (0.54-1.23) | 0.33 | 682.1 | ||
| Recessive | 0.64 (0.20-2.04) | 0.44 | 0.64 (0.20-2.05) | 0.45 | 682.4 | ||
| Overdominant | 0.86 (0.56-1.31) | 0.47 | 0.85 (0.55-1.31) | 0.47 | 682.5 | ||
| Multiplicative | 0.82 (0.57-1.18) | 0.28 | 0.82 (0.57-1.18) | 0.28 | 681.8 | ||
| rs10504473 | Codominant | 0.96 (0.63-1.47) | 0.87 | 0.97 (0.63-1.49) | 0.90 | 703.9 | |
| 0.74 (0.45-1.20) | 0.22 | 0.74 (0.45-1.20) | 0.23 | ||||
| Dominant | 0.88 (0.59-1.31) | 0.52 | 0.88 (0.59-1.32) | 0.54 | 703.4 | ||
| Recessive | 0.76 (0.51-1.13) | 0.17 | 0.75 (0.50-1.13) | 0.17 | 701.9 | ||
| Overdominant | 1.12 (0.79-1.59) | 0.53 | 1.13 (0.79-1.61) | 0.50 | 703.3 | ||
| Multiplicative | 0.86 (0.67-1.10) | 0.22 | 0.86 (0.67-1.10) | 0.23 | 702.3 |
#
Data was analyzed with unconditional logistic regression analysis adjusted for age and sex;
*
P values were not corrected by Bonferroni correction;
AIC, Akaike information criterion; OR, odds ratio; CI, confidence interval; Codominant, wild homozygote serves as the reference; Dominant, heterozygote and minor allele homozygote vs. wild homozygote; Recessive, minor allele homozygote vs. wild homozygote and heterozygote; Overdominant, heterozygote vs. wild homozygote and minor allele homozygote; Multiplicative, heterozygote and minor allele homozygote were weighted 1 and 2 respectively to wild homozygote.