Table 3.
Association of IL-17A rs2275913G>A and rs3748067C>T and IL-17F rs763780T>C with risk of gastric cancer
| Genotype of IL-17 | Patients | % | Controls | % | OR (95% CI)1 | P value |
|---|---|---|---|---|---|---|
| rs2275913G>A | ||||||
| GG | 121 | 37.12 | 161 | 49.39 | Ref. | |
| GA | 149 | 45.7 | 136 | 41.72 | 1.46 (1.03-2.06) | 0.03 |
| AA | 56 | 17.18 | 29 | 8.89 | 2.57 (1.51-4.43) | <0.001 |
| GA+AA | 205 | 62.88 | 165 | 50.61 | 1.65 (1.19-2.29) | 0.002 |
| rs3748067C>T | ||||||
| TT | 274 | 84.05 | 286 | 87.73 | Ref. | |
| TC | 34 | 10.43 | 30 | 9.2 | 1.18 (0.68-2.06) | 0.52 |
| CC | 18 | 5.52 | 10 | 3.07 | 1.88 (0.80-4.64) | 0.11 |
| TC+CC | 52 | 15.95 | 40 | 12.27 | 1.36 (0.85-2.17) | 0.18 |
| rs763780T>C | ||||||
| CC | 266 | 81.59 | 278 | 85.28 | Ref. | |
| CT | 38 | 11.66 | 33 | 10.12 | 1.20 (0.71-2.04) | 0.46 |
| TT | 22 | 6.75 | 15 | 4.6 | 1.53 (0.74-3.25) | 0.21 |
| CT+TT | 60 | 18.41 | 48 | 14.72 | 1.31 (0.85-2.03) | 0.21 |
1
Adjusted for sex, age, cancer history in the first relatives, alcohol drinking, cigarette smoking and H.pylori infection.