Table 1.
TRAIL genotypes and alleles frequencies in the patients with LDD and the controls, and their association with the risk of LDD
| Genotypes and alleles | Patients (n=153) | Controls (n=131) | χ2 | P value | OR (95% CI) |
|---|---|---|---|---|---|
| 1525 G/A, 1595 C/T | |||||
| 1525 GG/1595 CC | 46 (30.07) | 22 (16.79) | 1 | ||
| 1525 GA/1595 CT | 71 (46.41) | 66 (50.38) | 4.644 | 0.031 | 0.514 (0.280-0.946) |
| 1525 AA/1595 TT | 36 (23.53) | 43 (32.82) | 7.221 | 0.007 | 0.400 (0.204-0.786) |
| 1525 G/1595 C | 163 (53.27) | 110 (41.98) | 1 | ||
| 1525 A/1595 T | 143 (46.73) | 152 (58.02) | 7.199 | 0.007 | 0.635 (0.455-0.885) |
| 1289 C/A | |||||
| CC | 115 (75.16) | 102 (77.86) | 1 | ||
| CA | 33 (21.57) | 25 (19.08) | 0.28 | 0.597 | 1.171 (0.653-2.100) |
| AA | 5 (3.27) | 4 (3.05) | |||
| CA+AA | 38 (24.84) | 29 (22.14) | 0.285 | 0.593 | 1.162 (0.669-2.018) |
| C | 263 (85.95) | 229 (87.40) | 1 | ||
| A | 43 (14.05) | 33 (12.60) | 0.285 | 0.661 | 1.135 (0.697-1.846) |
| 1588 G/A | |||||
| GG | 119 (77.78) | 110 (83.97) | 1 | ||
| GA | 29 (18.95) | 19 (14.50) | 1.139 | 0.286 | 1.411 (0.748-2.659) |
| AA | 5 (3.27) | 2 (1.53) | |||
| GA+AA | 34 (22.22) | 21 (16.03) | 1.733 | 0.188 | 1.497 (0.819-2.734) |
| G | 267 (87.25) | 239 (91.22) | 1 | ||
| A | 39 (12.75) | 23 (8.78) | 2.284 | 0.131 | 1.518 (0.881-2.615) |
TRAIL, tumor necrosis factor related apoptosis-inducing ligand; LDD, lumbar disc degeneration; OR, odds ratio; CI, confidence interval.