Table 2.
Alleles and genotypes distribution of CTLA-4 polymorphisms in case and control groups
| Genotype/Allele | Case (n=120), n (%) | Control (n=120), n (%) | χ2 | P value | OR (95% CI) |
|---|---|---|---|---|---|
| Genotype | |||||
| 49A/G | |||||
| GG | 28 (23.3) | 44 (36.7) | - | - | 1 |
| AG | 62 (51.7) | 56 (46.7) | 3.344 | 0.067 | 1.740 (0.959-3.157) |
| AA | 30 (25.0) | 20 (16.6) | 5.273 | 0.022 | 2.357 (1.127-4.930) |
| 318C/T | |||||
| CC | 98 (81.7) | 70 (58.3) | - | - | 1 |
| CT | 20 (16.7) | 46 (38.3) | 14.893 | 0.000 | 0.311 (0.169-0.570) |
| TT | 2 (1.6) | 4 (3.4) | 1.481 | 0.224 | 0.357 (0.064-2.004) |
| CT60A/G | |||||
| AA | 77 (64.2) | 59 (49.2) | 4.441 | 0.035 | 2.610 (1.047-6.510) |
| AG | 35 (29.2) | 45 (37.5) | 0.826 | 0.363 | 1.556 (0.598-4.050) |
| GG | 8 (6.6) | 16 (13.3) | - | - | 1 |
| Allele | |||||
| 49A/G | |||||
| G | 118 (49.2) | 144 (60.0) | - | - | 1 |
| A | 122 (50.8) | 96 (40.0) | 5.681 | 0.017 | 1.551 (1.080-2.226) |
| 318C/T | |||||
| C | 216(90.0) | 186(77.5) | - | - | 1 |
| T | 24(10.0) | 54(22.5) | 13.777 | 0.000 | 0.383(0.228-0.643) |
| CT60A/G | |||||
| G | 51 (21.3) | 77 (32.1) | - | - | 1 |
| A | 189 (78.7) | 163 (67.9) | 7.202 | 0.007 | 1.751 (1.160-2.641) |