Table 3.
Linkage disequilibrium and haplotype analysis of alleles in -31G/C, -625G/C, 9194A/G and 9809T/C
| Haplotype site1-site2-site3-site4 | Patientsa 2n=200 (%) | Controlsa 2n=198 (%) | χ2 | P | OR (95% CI) |
|---|---|---|---|---|---|
| G-G-A-C | 28 (14.0) | 56 (28.3) | - | - | 1.00 |
| C-G-A-C | 10 (5.0) | 8 (4.0) | 3.132 | 0.077 | 2.50 (0.89-7.03) |
| C-G-A-T | 31 (15.5) | 33 (16.7) | 3.457 | 0.063 | 1.88 (0.96-3.66) |
| C-G-G-C | 78 (39.0) | 56 (28.3) | 12.790 | 0.000 | 2.79 (1.58-4.92) |
| G-C-A-T | 53 (26.5) | 45 (22.7) | 7.884 | 0.005 | 2.36 (1.29-4.30) |
a
Nine haplotypes that had a frequency of less than 1% were excluded from analysis;
controls 30 and cases 20, respectively.