Table 3.
Passage | Structural abnormalities | Aneuploidy | Polyploidy | Hyperdiploidy | Breaks or gaps |
---|---|---|---|---|---|
Standard* | ≤2 % | ≤18 % | ≤4 % | ≤2 % | ≤8 % |
10-19 | 0/3500 | 265/3500 (7.57%) | 1/3500 (0.03%) | 22/3500 (0.63%) | 0/3500 |
20-29 | 0/6000 | 538/6000 (8.97%) | 3/6000 (0.05%) | 49/6000 (0.82%) | 1/6000 (0.17%) |
30-39 | 0/4500 | 423/4500 (9.4%) | 1/4500 (0.02%) | 40/4500 (0.89%) | 1/4500 (0.02%) |
40-50 | 0/9000 | 945/9000 (10.5%) | 7/9000 (0.08%) | 113/9000 (1.26%) | 7/9000 (0.08%) |
*Chinese pharmacopeia, volume III, 2010 edition