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. 2015 Jun 22;12(3):4055–4062. doi: 10.3892/mmr.2015.3969

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Effect of TNF-α and Tan IIA on EPC vasculogenesis ability in vitro. (A) Quantitative analysis of total length of the tubes formed on Matrigel^® for each experimental group. (B) Light micrographs showing typical tubules (magnification, ×200; scale bar, 100 μm). TNF-α impaired EPC vasculogenesis ability in vitro, while Tan IIA dose-dependently increased cell vasculogenesis in vitro. EPCs without treatment served as the control group. Data are presented as the mean ± standard deviation (n=5). ^#P<0.01 vs. control group; ^**P<0.01 vs. TNF-α group. EPC, endothelial progenitor cells; TNF-α, tumor necrosis factor-α; Tan IIA, tanshinone IIA.