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. 2015 Jun 22;12(3):4055–4062. doi: 10.3892/mmr.2015.3969

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Effects of TNF-α and Tan IIA on EPC paracrine function. ELISAs were used to determine the effect of TNF-α and Tan IIA on (A) MCP-1, (B) IL-6 and (C) sCD40L content of EPCs. TNF-α increased EPC secretion of MCP-1, IL-6 and sCD40L, while Tan IIA dose-dependently decreased cell paracrine function. EPCs without treatment served as the control group. Data are presented as the mean ± standard deviation (n=3). ^$P<0.05 vs. control group; ^#P<0.01 vs. control group; ^*P<0.05 vs. TNF-α group; ^**P<0.01 vs. TNF-α group. EPC, endothelial progenitor cells; TNF-α, tumor necrosis factor-α; Tan IIA, tanshinone IIA; MCP-1, monocyte chemoattractant protein-1 (MCP-1); IL-6, interleukin-6; sCD40L, soluble CD40 ligand.