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. 2015 Jun 15;12(3):4141–4148. doi: 10.3892/mmr.2015.3931

Figure 3.

Figure 3

Effects of disease modifying antirheumatic drugs on the expression of HPGD in the RA-FLS. (A) The expression of HPGD in the RA-FLS was determined by western blotting (n=4). RA-FLS were serum-starved for 2 h and subsequently treated with SSZ (10 µg/ml), HCQ (10 µM), MTX (10 nM) or I (10 µg/ml) for 24 h. (B) The graphs revealed the ratio of HPGD to ACTB, as determined by ImageJ software (*P≤0.001, **P=0.003, compared with control). CON, control; SSZ, sulfasalazin; HCQ, hydroxychloroquine; MTX, methotrexate; I, infliximab; HPGD, 15-hydroxyprostaglandin dehydrogenase; ACTB, β-actin; RA-FLS, rheumatoid arthritis fibroblast-like synoviocytes.