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. 2015 May 22;12(3):3432–3438. doi: 10.3892/mmr.2015.3815

Figure 4.

Figure 4

Overexpression of EGFR is correlated with HIF-1α and CD146 in human AdCC tissue. (A) Expression of EGFR was positively correlated with HIF1-α and CD146 (P<0.05, r=0.2154, n=104; P<0.001, r=0.4701, n=104, respectively) and the (B) expression of HIF-1α was significantly correlated with CD146 (P<0.001, r=0.3491, n=104) in human NSG, PMA and AdCC tissues by analyzing the tissue microarray immunohistochemical staining. (C) Hierarchical clustering of immunohistochemical results of human AdCC with EGFR, HIF-1α and CD146 (statistics including AdCC tissue only n=74). EGFR, epidermal growth factor receptor; NSG, normal salivary gland; PMA, polymorphism adenoma; AdCC, adenoid cystic carcinoma; HIF-1α, hypoxia-inducible factor-1α.