Table III.
Top 10 upregulated and downregulated genes in the synovial membrane of patients with OA.
| A, Upregulated genes
| ||||
|---|---|---|---|---|
| Entrez ID | Gene symbol | Combined ES | P-value | Gene name |
| 221895 | JAZF1 | −1.6865 | 0.004003 | JAZF zinc finger 1 |
| 59345 | GNB4 | −1.6774 | 0.004003 | Guanine nucleotide binding protein (G protein), β polypeptide 4 |
| 3070 | HELLS | −1.6193 | 0.005903 | Helicase, lymphoid-specific |
| 9749 | PHACTR2 | −1.5892 | 0.005903 | Phosphatase and actin regulator 2 |
| 9645 | MICAL2 | −1.5726 | 0.006072 | Microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| 10974 | C10orf116 | −1.5715 | 0.006072 | Adipogenesis regulatory factor |
| 283310 | OTOGL | −1.5624 | 0.006072 | Otogelin-like |
| 26230 | TIAM2 | −1.5531 | 0.006563 | T-cell lymphoma invasion and metastasis 2 |
| 51194 | IPO11 | −1.5378 | 0.006822 | Importin 11 |
| 1404 | HAPLN1 | −1.5176 | 0.007348 | Hyaluronan and proteoglycan link protein 1 |
| B, Downregulated genes
| ||||
|---|---|---|---|---|
| Entrez ID | Gene symbol | Combined ES | P-value | Gene name |
| 27242 | TNFRF21 | 1.8378 | 0.003981 | Tumor necrosis factor receptor superfamily, member 21 |
| 84225 | ZMYND15 | 1.8026 | 0.003981 | Zinc finger, MYND-type containing 15 |
| 9562 | MINPP1 | 2.0472 | 0.004003 | Multiple inositol-polyphosphate phosphatase 1 |
| 3600 | IL15 | 1.9554 | 0.004003 | Interleukin 15 |
| 3487 | IGFBP4 | 1.7005 | 0.004003 | Insulin-like growth factor binding protein 4 |
| 54504 | CPVL | 1.6845 | 0.004003 | Carboxypeptidase, vitellogenic-like |
| 9450 | LY86 | 1.6796 | 0.004003 | Lymphocyte antigen 86 |
| 147798 | TMC4 | 1.6305 | 0.004882 | Transmembrane channel-like 4 |
| 834 | CASP1 | 1.5939 | 0.005903 | Caspase 1, apoptosis-related cysteine peptidase |
| 83401 | ELOVL3 | 1.8314 | 0.006822 | ELOVL fatty acid elongase 3 |
ES, effect size; OA, osteoarthritis.