Table IV.
Top 10 enriched GO terms among the DE genes in patients with OA compared with controls.
| GO ID | Term | P-value | Genes |
|---|---|---|---|
| GO:0006955 | Immune response | 0.000129438 | ITGAL, GIMAP5, INPP5D, LAX1, GZMA, IRF1, CST7, SKAP1, CD55, TNFRSF4, CD37, CX3CR1, HLA-C, CXCL3 |
| GO:0002252 | Immune effector process | 0.000288619 | ITGAL, GIMAP5, INPP5D, IRF1, CD55, TNFRSF4, CD37, CX3CR1 |
| GO:0002920 | Regulation of humoral immune response | 0.000308832 | GIMAP5, CD55, CD37 |
| GO:0042981 | Regulation of apoptotic process | 0.000510947 | PRKCH, SKP2, PAFAH2, TMBIM6, GIMAP5; DYRK2, ACTN1, FEM1B, INPP5D, GZMA, IRF1, TNFRSF4, CX3CR1, ARHGEF3 |
| GO:0051250 | Negative regulation of lymphocyte activation | 0.000517654 | GIMAP5, INPP5D, LAX1, IRF1 |
| GO:0045589 | Regulation of regulatory T cell differentiation | 0.000531439 | GIMAP5, IRF1 |
| GO:0043067 | Regulation of programmed cell death | 0.000551712 | PRKCH, SKP2, PAFAH2, TMBIM6, GIMAP5, DYRK2, ACTN1, FEM1B, INPP5D, GZMA, IRF1, TNFRSF4, CX3CR1, ARHGEF3 |
| GO:0050776 | Regulation of immune response | 0.000555143 | PRKCH, ITGAL, GIMAP5, INPP5D, IRF1, SKAP1, CD55, CD37, HLA-C |
| GO:0002684 | Positive regulation of immune system process | 0.000593511 | PRKCH, ITGAL, GIMAP5, INPP5D, IRF1, SKAP1, CD55, TNFRSF4, CD37 |
| GO:0010941 | Regulation of cell death | 0.000708372 | PRKCH, SKP2, PAFAH2, TMBIM6, GIMAP5, DYRK2, ACTN1, FEM1B, INPP5D, GZMA, IRF1, TNFRSF4, CX3CR1, ARHGEF3 |
GO, gene ontology; DE, differentially expressed; OA, osteoarthritis; ITGAL, Integrin, α L; GIMAP5, GTPase, IMAP family member 5; INPP5D, inositol polyphosphate-5-phosphatase; LAX1, lymphocyte transmembrane adaptor 1; GZMA, granzyme A; IRF1, interferon regulatory factor 1; SKAP1, src kinase associated phosphoprotein 1; TNFRSF4, tumor necrosis receptor superfamily, member 4; CX3CR1, CX3C chemokine receptor 1; HLA-C, humna leukocyte antigen C; CXCL3, chemokine (C-X-C motif) ligand 3; PRKCH, protein kinase C, η; SKP2, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; PAFAH2, platelet-activating factor acetylhydrolase 2, 40kDa; TMBIM6, transmembrane BAX inhibitor motif containing 6; DYRK2, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; ACTN1, Actinin, α 1; FEM1B, Fem-1 homolog b (C. elegans); ARHGEF3, ρ guanine nucleotide exchange factor (GEF) 3.