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. 2015 May 25;12(3):3400–3408. doi: 10.3892/mmr.2015.3841

Figure 8.

Figure 8

(A and B) Effects of SAN on the protein expression of c-caspase 3 and -9 as well as Bax and Bcl-2. The protein levels of c-caspase 3 and -9 as well as Bax were increased following stimulation with Ang II (10 µM) for 24 h. Levels of Bcl-2 were markedly decreased following a further 24-h-incubation with Ang II. Treatment with (Ab) SAN (0.5 µM) and (Bb) NAC (1 mM), decreased the levels of c-caspase 3 and -9 as well as Bax, while markedly increasing Bcl-2 levels. Values are expressed as the mean ± standard error of the mean for three independent experiments, #P<0.01 vs. control; *P<0.01 vs. Ang II group. Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein; SAN, sanguinarine; Ang, angiotensin; NAC, N-acetylcysteine; c-caspase, cleaved caspase.