Table II.

Genotype and clinical data of the family members.

Family member	Gender	Age (years)	p.Asp496* mutation	PS activity (%)	Total PS antigen (%)	Free PS antigen (%)	Clinical manifestation
I- 1	M	82	ND	ND	ND	ND	Negative
I- 2	F	79	ND	ND	ND	ND	Negative
II- 3	F	52	Positive	41	58	52	Large area cerebral infarct
II- 4	M	50	Positive	37	46	50	Large area cerebral infarct
III- 5	M	25	Positive	32	50	35	Negative
III- 6	F	22	Negative	88	114	97	Negative
III- 7	F	26	Negative	85	80	123	Negative
III- 8	F	24	Positive	39	40	43	Negative
III- 9	M	21	Negative	80	73	83	Negative

Reference range: PS activity, 65–130%;total PS antigen, 70–130%; free PS antigen, 65–130%. M, male; F, female; ND, not determined.