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. 2015 May 15;12(3):3416–3422. doi: 10.3892/mmr.2015.3789

Figure 1.

Figure 1

Effects of microRNA (miR)-141 overexpression on the migration of HGC-27 and SGC-7901 gastric cancer cells transfected with an miR-141 precursor (25 nM), a negative control (Negative, 25 nM), or neither of the above (Control) for 24 h were subjected to quantitative polymerase chain reaction (qPCR), MTT analysis, a cell migration assay, and a wound healing assay. (A) Relative expression levels of miR-141 in HGC-27 and SGC-7901 cells 24 h post-transfection were measured by qPCR. *P<0.05, vs. Control. (B) Effects of miR-141 overexpression on the proliferation of HGC-27 and SGC-7901 cells were measured by MTT assay 24 h post-transfection. (C and D) Effects of miR-141 overexpression on the migration of HGC-27 and SGC-7901 cells were measured by cell migration assay 24 h post-transfection, and were (C) presented as phase contrast micrographs and (D) number of cells. (E and F) Effects of miR-141 overexpression on the migration of (E) HGC-27 and (F) SGC-7901 cells measured by wound healing assay 24 h post-transfection. Data are expressed as the mean ± standard error from three independent experiments. Scale bars represent 100µm. *P<0.05, **P<0.01, vs. Negative. OD, optical density.