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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Neurobiol Dis. 2015 Mar 31;78:172–195. doi: 10.1016/j.nbd.2015.02.031

Fig. 2. Normal DA neuronal counts and levels but altered DA metaboli sm in aged G2019S mice.

Fig. 2

(a) Stereological counts of DA neurons (TH positive) in 18–20 month old WT (N=5) and HOMO KI mice (N=3) are similar. (b) Examples of TH immuno -stained sections from WT and HOMO KI mice at the level of the nigra and striatum revealed similar neuron and process density. Striatal axonal neurochemistry was measured by HPLC measurements at 6 and 18 months (n=4 to 9 per group) (c) DA (d) DOPAC (e) HVA (f) metabolism ratio DOPAC/DA (g) metabolism ratio HVA/DA. Data expressed as mean ± SEM and analyzed by Student’s T-test (a) or 2-way RM ANOVA (age and genotype as factors) followed by Tukey’s Post hoc comparisons (c–g). *p<0.05, ** p<0.01, *** p<0.001