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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Neurobiol Dis. 2015 Mar 31;78:172–195. doi: 10.1016/j.nbd.2015.02.031

Fig. 3. Extracellular release of basal and amphetamine-stimulated DA is normal at 6 months, but impaired by 12 months in G2019S KI mice.

Fig. 3

Microdialysis collections taken from the striatum of freely moving WT, HET and HOMO mice (N=8–11 per genotype, per age) and analyzed by HPLC (a) Average extracellular baseline levels of DA at 6 months (b) time course of average baseline and amphetamine stimulated DA levels at 6 months (c) time course of % response to amphetamine (normalized to individual baselines) at 6 months (d) extracellular baseline levels of DA at 12 months (e) time course of baseline and amphetamine stimulated DA levels e at 12 months (f) time course of % response to amphetamine (normalized to individual baselines) at 12 months. N=8 mice per group. Data expressed as mean ± SEM, analyzed by 2-way RM ANOVA (time and genotype as factors) followed by Bonferroni’s multiple comparisons. *p<0.05, ** p<0.01, *** p<0.001.