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. Author manuscript; available in PMC: 2015 Dec 11.
Published in final edited form as: Cell Rep. 2014 Nov 26;9(5):1959–1965. doi: 10.1016/j.celrep.2014.10.065

Fig. 2. Protein half-life differences in distinct sets of proteins.

Fig. 2

(A) Contributions of degradation (Kdeg) and protein dilution due to cell growth (Kdil) in S. cerevisiae and S. pombe. Log2(Kdeg/Kdil) ratios define three classes of protein abundance regulation: class I (Kdeg ≥ 2xKdil), class II (0.5xKdil ≤ Kdeg ≥ 2xKdil) and class III (Kdeg ≤ 2xKdil). (B) Gene Ontology (GO) analysis of class I and class II proteins in S. cerevisiae. (C) Comparison of protein abundances with ribosome footprint data in S. cerevisiae for proteins of class I (purple), class II (orange) and class III (green). (D) Comparison of protein abundances between class I, II and III. (E) Sequence analysis of the 5′UTR (30-mer ahead of start codon) of the 10% most abundant proteins in S. cerevisiae.