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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Proteins. 2015 May 8;83(6):1151–1164. doi: 10.1002/prot.24808

Fig. 1. OSPREY Protein Design Overview.

Fig. 1

The OSPREY protein design software [20] takes as input an initial protein structure, a rotamer library, an energy function to rank conformations, and the allowed flexibility of the protein during the search. OSPREY uses DEE criteria to prune rotamers from the search that are guaranteed to not participate in any low energy conformations. The rotamers remaining after pruning are input to the conformation enumeration step where conformations are enumerated in order of lowest energy, or in the case of continuous rotamers, in order of lowest energy bound.