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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Inflamm Bowel Dis. 2015 Jan;21(1):19–30. doi: 10.1097/MIB.0000000000000242

Figure 3.

Figure 3

Figure 3

TCR repertoire diversity of T cell populations from anatomically distinct sites: TCR Vβ hypervariable domains were deep sequenced from 105 Helios+ or Helios− FOXP3+ Tregs, and CD38+, CD161+, or CD161− FOXP3− CD45RA− Teff sorted from specimens in Figure 2. (a) Sequence data from the three donors used for each cell and specimen type was pooled, and each unique sequence within a given pool was assigned a rank, based upon its copy number, which was then plotted against its copy number on a log scale to reflect the overall distribution of clonal diversity of a cell type within each of the specimen types shown. (b) The total number of unique TCR sequences (regardless of copy number) for each cell type in MLN (white bars), inflamed (light grey bars) or non-inflamed colon LP (dark grey bars) from 3 UC patients or colon LP from 3 patients without UC (black bars) is shown. Bars reflect the means and standard deviations of the three independent donors for each specimen type.