Table 1.
Characteristic | Muscular Dystrophy Cohort | Control for DMD Cohort | P values | |||
---|---|---|---|---|---|---|
DMD | BMD | LGMD | All | |||
No. (%) or Mean ± SD | No. (%) or Mean ± SD | No. (%) or Mean ± SD | No. (%) or Mean ± SD | No. (%) of Mean ± SD | ||
Number | 35 (73%) | 11 (23%) | 2 (4%) | 48 (100%) | 33 (100%) | |
Age, y | 13 ± 3 | 14 ± 3 | 14 ± 2 | 13 ± 3 | 13 ± 3 | 0.43 |
Ethnicity | ||||||
Hispanic | 5 (14%) | 0 (0%) | 1 (50%) | 6 (13%) | N/A | |
Non-Hispanic | 30 (86%) | 11 (100%) | 1 (50%) | 42 (88%) | N/A | |
Race | ||||||
Caucasian | 29 (83%) | 10 (91%) | 1 (50%) | 40 (83%) | N/A | |
Asian | 2 (6%) | 0 (0%) | 0 (0%) | 2 (4%) | N/A | |
African American | 3 (9%) | 1 (9%) | 1 (50%) | 5 (10%) | N/A | |
Other | 1 (3%) | 0 (0%) | 0 (0%) | 1 (2%) | N/A | |
Vital signs | ||||||
SBP (mmHg) | 109 ± 13 | 111 ±9 | 95 ± 3 | 109 ± 12 | 115 ± 10 | 0.02 |
DBP (mmHg) | 65 ± 8 | 64 ± 9 | 60 ± 5 | 65 ± 7 | 64 ± 7 | 0.76 |
Heart Rate (bpm) | 92 ± 14 | 79 ± 12 | 93 ± 1 | 89 ± 15 | 67 ± 13 | <0.001 |
BMI (kg/m2) | 24 ± 7 | 20 ± 3 | 18 ± 2 | 23 ± 7 | 22 ± 6 | 0.68 |
Glucocorticoid Use | 0.003 | |||||
Past users | 6 (17%) | 0 (0%) | 1 (50%) | 7 (15%) | N/A | |
Current user | 24 (69%) | 4 (36%) | 1 (50%) | 29 (61%) | N/A | |
Never used | 5 (14%) | 7 (64%) | 0 (0%) | 12 (25%) | N/A | |
Cardiac Medication Use | 0.76 | |||||
Past users | 1 (3%) | 0 (0%) | 0 (0%) | 1 (2%) | N/A | |
Current user | 13 (37%) | 4 (36%) | 0 (0%) | 17 (36%) | N/A | |
Never used | 21 (60%) | 7 (64%) | 2 (100%) | 30 (63%) | N/A | |
CoQ10 Use | 0.99 | |||||
Past users | 3 (9%) | 2 (18%) | 0 (0%) | 5 (10%) | N/A | |
Current user | 8 (23%) | 1 (9%) | 0 (0%) | 9 (19%) | N/A | |
Never used | 24 (69%) | 8 (73%) | 2 (100%) | 34 (71%) | N/A |
P-values are comparisons between the controls (N=33) and the entire MD cohort (N=48) for characteristics available in the entire cohort and are between MD diagnoses for characteristics only applicable to the MD group.
Abbreviations: DMD – Duchenne muscular dystrophy, BMD – Becker muscular dystrophy, LGMD – Limb girdle muscular dystrophy, SD – standard deviation, y – years, BMI – Body mass index, SBP – systolic blood pressure, DBP – diastolic blood pressure, mmHg – millimeters of mercury, bpm – beats per minute, N/A – not applicable