Table 1.

Summary of several key considerations in choosing or developing infected animal models for evaluation of tissue engineering-based strategies

Considerations for Infected Models in Tissue Engineering
Host Animal
	Size
	Strain
	Species
Defect
	Size
	Anatomical location
	Accompanying systemic metabolic/immunologic deficiencies
Inoculum
	Species
	Strain
	Concentration
	Vehicle
Evaluation
	Clinical signs
	Terminal analyses (CFU counting, histology)
	Real-time analyses (irrigation, radiography, bioluminescent imaging)