Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Cancer Res. 2015 Jun 4;75(15):2999–3009. doi: 10.1158/0008-5472.CAN-15-0840

Figure 2. 2-HG-mediated increase in HIF-1α and PDK3 levels result in reduced PDH activity.

Figure 2

Western blots and quantification for PDK3 (A,B) and HIF-1α (C,D) in U87 and NHA models. PDH activity in IDH1 wild-type cells treated with 2-HG in U87 (E) and NHA (F) models. Western blots and quantification for PDK3 (G,H) and HIF-1α (I,J) in U87 and NHA IDH1 wild-type cells treated with 2-HG.