Figure 5. Glutamate production from glucose is reduced in both U87 and NHA IDH1 mutant cells.
Quantification of glutamate produced from 1-13C-glucose and 3-13C-glutamine (13C-GLU) and total glutamate levels (1H-GLU) in U87 (A) and NHA (B) models. Quantification of 2-HG produced from 1-13C-glucose and 3-13C-glutamine (13C-2-HG) and total 2-HG levels (1H-2-HG) in both models (C).