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. Author manuscript; available in PMC: 2016 Aug 4.
Published in final edited form as: Biochemistry. 2015 Jul 22;54(30):4692–4703. doi: 10.1021/acs.biochem.5b00536

Table 2.

Inhibitory potency of compounds 1–7 against against Mycoplana ramosa APAH and human HDAC8
IC50 (µM)
Compound APAH HDAC8
1 0.27 ± 0.03a 0.26 ± 0.02
38 ± 6a
2 26 ± 3a 12 ± 1
3 0.39 ± 0.03a 14 ± 1
4 0.17 ± 0.01 120 ± 10
5 0.13 ± 0.01 19 ± 2
6 0.068 ± 0.006 5.3 ± 0.8
7 0.15 ± 0.02 2.2 ± 0.2
a

Values previously reported in ref. 33.