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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Leukemia. 2015 Mar 6;29(8):1771–1778. doi: 10.1038/leu.2015.58

Figure 3. Runx1 activity is required for Cbfb-MYH11 induced defects during definitive hematopoiesis.

Figure 3

Figure 3

Figure 3

(A) Graph of the number of the lineage negative (lin-) cells per ml from the bone marrow of adult mice of the indicated genotypes 2 weeks after the induction of Cbfb-MYH11 expression. (B) Graph of percentage of lin-cells that were BrdU+ in the bone marrow of adult mice of the indicated genotypes 1 week after the induction of Cbfb-MYH11 expression. * indicates p≤0.05 as compared to Runx1+/+ mice. # indicates p≤0.05 as compared to Mx1-Cre+, Cbfb+/56M, Runx1+/+ mice. (C) Representative FACs plots of Il1rl1 and Csf2rb and (D) Kit, ScaI, CD34 and FcRγII/III staining of lin-bone marrow from adult mice of the indicated genotypes 2 weeks after the induction of Cbfb-MYH11 expression. N≥3 for each genotype.