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A) Agonist binding, hPXR-RXRα heterodimerization and hPXR-coactivator recruitment are the three key steps for the precise regulation of hPXR on target gene expression (top panel). B) The putative phosphorylation of Ser350 of PXR halts transcriptional activation of target genes by preventing hPXR heterodimerization with RXRα (bottom panel).
