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. Author manuscript; available in PMC: 2016 Aug 4.
Published in final edited form as: Structure. 2015 Jul 16;23(8):1470–1481. doi: 10.1016/j.str.2015.06.009

Figure 1. CBR inhibitors.

Figure 1

(A) Structure of the CBR hydroxamidine inhibitor CBR703 (compound of Example 1 of Li et al., 2001a).

(B) Structure of the CBR pyrazole inhibitor CBRP18 (compound of Example 18 of Li et al., 2001b).

(C) RNAP-inhibitory activities. IC50: concentration resulting in 50% inhibition.

(D) Growth-inhibitory activities. MIC: minimum inhibitory concentration. Antibacterial activities against Gram-negative enteric bacteria are limited to efflux-deficient strains (e.g., E. coli D21f2tolC). MICs against wild-type strains (e.g., E. coli type strain ATCC 25922) are >50 μg/ml.