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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Clin Cancer Res. 2015 Apr 10;21(15):3462–3470. doi: 10.1158/1078-0432.CCR-14-2681

Figure 4. Combination of MBZ with elacridar.

Figure 4

A. IC50 curve of GL261 glioma cells with elacridar (ELD). IC50=5.8 μM.

B. Inhibition of GL261 cells by MBZ (0.25 μM), ELD (1 or 5 μM) or the combination. Cells were incubated with the indicated drugs for 72 h and the living cells were measured by the colorimetric assay.

C. ELD elevated the average B/P ratios of MBZ in mice.