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. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: Clin Cancer Res. 2015 Apr 10;21(15):3462–3470. doi: 10.1158/1078-0432.CCR-14-2681

Table 1.

Pharmacokinetics of MBZ polymorphs in mice.

		Plasma				Brain

Polymorph	Detection	T_1/2 (h)	T_max (h)	C_max (ng/ml)	AUC_0-24h (h*ng/ml)	T_1/2 (h)	T_max (h)	C_max (ng/g)	AUC_0-24h (h*ng/g)	B/P
A	MBZ	3.23	1	379.3	3052
B	MBZ	3.18	6	2778.3	26474
C	MBZ	0.90	4	2553.3	16039	1.64	4	2016	13134	0.82

A	MBZ-NH₂		2.5	201.3	2841
B	MBZ-NH₂		8	1656.7	18583
C	MBZ-NH₂		8	1416.7	10516		8	201.6	1336	0.13

A	MBZ-OH		1	32.1	247
B	MBZ-OH		8	744.7	4970
C	MBZ-OH		6	951.7	5781		8	794.3	5427	0.94

		Plasma			Brain			B/P

Drug	Detection	T_max (h)	C_max (ng/mL)	AUC_0-8h (h*ng/mL)	T_max (h)	C_max (ng/g)	AUC_0-8h (h*ng/g)	AUC_0-8h	Significant?
MBZ	MBZ	4	2553.3	15340	4	2016.0	11510	0.75
ELD+MBZ	MBZ	2.5	1433.3	8636	2.5	1459.7	8904	1.03	No

MBZ	MBZ-NH2	8	1416.7	8264	8	201.6	1010	0.12
ELD+MBZ	MBZ-NH2	2.5	1191.7	7826	8	387.8	2386	0.30	Yes

MBZ	MBZ-OH	2.5	810.0	4679	8	794.3	4135	0.88
ELD+MBZ	MBZ-OH	2.5	491.0	2680	2.5	712.6	3475	1.30	No

Pharmacokinetics of MBZ polymorphs in mice.